I have an Astell & Kern SR25 MKII DAP (digital audio player) and I use it quite frequently. The sound quality far surpasses what my phone can produce when connected to any of my speakers or headphones.

It plays FLAC files and any other audio file type you can think of. And it acts as an offline music library when needed (64 GB of memory plus a 1TB microSD).

The better the headphones/speakers I use, the more it outshines anything coming out of my other electronic devices. I use it almost every day.

You are saying that sucralose (or a metabolite thereof) could alkylate DNA - and theoretically proteins too - correct? Like what sulfur mustard gas does?

I did a quick search and couldn’t find any papers demonstrating a mechanism of action for that, although I skimmed a few that postulated that a dichlorinated hydrolysis product might be the true carcinogenic agent. Do you know of any studies that demonstrate that the alkylation can happen, either in vitro or (ideally) in vivo? Or maybe some better search terms to use, that could be my issue…

I am truly curious about this, I never knew the chemical structure of sucralose until I read your comment and subsequently looked it up.

Thank you, I just finished the whole thing. It was a great read, and now I need to go and wipe my eyes from all these onions I’ve been chopping. :)

I appreciate the elaboration and if I understand you correctly, I definitely think I agree.

The way I see it, if the instances & communities that make up the Fediverse grow like a garden (rather than an invasive weed - please bear with this analogy, lol) then eventually we should get small but active plots with new ghost pepper variants or even duran trees (talk about deranged!) that people can check out or share with those that are interested. That would be very cool, and would be a maturation I look forward to and will contribute to as best I can.

Exactly. I don’t understand why so many people have this mentality of ‘the fediverse must grow, or it’s a failure’, but I think a lot of them are from the recent reddit exodus (I am too, for the record) and are addicted to the firehose of content that a massive social media platform brings.

I participated less and less on reddit in recent years, after joining in 2007, partly because it became such a behemoth. Nowadays, I am enjoying the modest size of my lemmy instance and the values I’ve seen espoused throughout. It’s like a small(er) get together of like-minded people rather than an open-door rager - the first has always had more appeal to me, personally.

I haven’t see any measurable proof of one, or any experiment proposed that would render the idea of a soul falsifiable or not. Honestly, the current debate in philosophy/neuroscience on the existence (or non-existence) of free-will seems like a more important question, that if answered in the negative would have major implications on even the definition of the word ‘soul’.

Fun question though, I’ve enjoyed reading the diversity of thought on the matter in this thread. :)

Seems like I read this same headline a few times each year. Soon, rampant heat illness/stroke is going to make the recent pandemic look like a tiny blip when it comes to human mortality data.