You can!
Add Steamtinkerlaunch to your steam proton list with protonup‐qt Then, select it under the force compatibility menu. From there, just click the run vortex mod manager button.
You can also run steamtinkerlaunch standalone, which is what I did for cyberpunk2077, but I feel like I did more manual file moving than I had to.
Edit: can’t spell today
I think this will end with playstation making yet another launcher on PC. No paying Gabe a cut, PSN all they want, tight review control. Really hope it doesn’t come to that.